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Research Area C: Cellular and Molecular Principles of Inflammation

Leader of the RA: Dieter Kabelitz (immunology), Thomas Roeder (immunology & physiology)

This Research Area makes use of state-of-the-art transgenic and knock-out/knock-in technologies to address the mechanisms of cellular interactions between defined molecules relevant for the inflammatory response. Proven excellence comprises the fields of cytokine receptor signaling (e.g., IL-6/gp130, IL-15, IL-26, TNFα, CD95, FasL), NFkB signaling and the immuno-biology of epithelial cells, macrophages, mast cells and T-­lymphocyte subpopulations. The identifycation and functional characterization of antimicrobial peptides and proinflammatory fungal lipids is a local strong­hold. Sophisticated cell culture systems and innova­tive biochemical separation and functionnal read-out technologies are used to investigate the signaling pathways involved in the cellular regulation of in­flammation.

Scientists (young/new scientists underlined)

Dieter Adam, Sabine Adam, Alexander Arlt, Thomas Bosch, Ernst Brandt, Rainer Duden, Helmut Fickenscher, Andreas Frey, Jürgen Harder, Enno Hartmann, Ottmar Janssen, Wolfgang Jelkmann, Kyeong-HeeLee, Matthias Leippe, Edmund Maser, Rolf Mentlein, Ulrich Mrowietz, Ralf Paus, Frank Petersen, Rainer Podschun, Jürgen Prestin, Kay Uwe Römer, Stefan Rose-John, Philip Rosenstiel, Paul Saftig, Jens-Michael Schröder, Hinrich Schulenburg, Stefan Schütze, Martina Spehlmann, Norbert Tautz, Thomas Valerius, Michael Winkler

Resources

confocal laserscan microscopy (Zeiss LSM510), FACSAria, multiphoton microscope (Lavision TriMScope), systematic analytical technologies for the molecular interactions on the subcellular level, state-of-the-art mass spectrometry and lipid chemistry, 2-D differential gel electrophoresis (DIGE) proteome analysis, automated siRNA platform with genome wide libraries.

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