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Research Area D: Complex Model Systems of Inflammation

Leader of the RA: Stefan Ehlers (biology of infection), Werner Solbach (medical microbiology & biology of infection)

This Research Area provides the cluster with multi­cellular, organ, and animal models to study complex interactions in barrier organs at the molecular level. Established model systems include:  the isolated and perfused mouse lung, experimental infections (tuberculosis, leishmaniasis, and sepsis), autoimmunity (antibody-mediated blister formation, allergic encephalomyelitis) and trauma (overventilation, UV irradiation, wound repair) affecting the lung, the skin, and blood vessels. Transgenic mouse models to mimic human disease pathophysiology and to test innovative therapeutic strategies are constantly refined including conditional mutant mice. Biosafety Level III laboratory facilities (S3) including animal space are available. In vivo analysis of T cell migration and differen­ tiation in several rodent models of antigenic stimulation is a local stronghold, and sophisticated in vivo imag­ing facilities are being established. The combination of “close-to-clinical-reality” model systems facilitates translation of basic principles of inflammatory responses in barrier organs into diagnostic improvements and therapeutic and preventive interventions.

Scientists (young/new scientists underlined)

Rainer Adelung, Jabbar Ahmed, Thomas Bosch, Marc Ehlers, Hanna Erdmann, Heinz FehrenbachGuntram Grassl, Christoph Hölscher, Johannes Knobloch, Jörg Köhl, Peter König, Tamas Laskay, Hendrik Lehnert, Georg Lutter, Rudolf Manz, Stefan Niemann, Stephan Ott, Ehrhardt Proksch, Norbert Reiling, Philip Rosenstiel, Jan Rupp, Sabine Rüsch-Gerdes, Paul Saftig, Ulrich Schaible, Ruth Schmitz-Streit, Thomas Schwarz, Philipp Steven, Norbert Weiler, Jürgen Westermann, Detlef Zillikens

Resources

BSL 2 and 3 (200 sqm.) laboratory for mouse experiments; Imaging: Berthold Night Owl (fluorescence and bioluminescence imaging), Mauna Kea Cellvisio (fiberoptic fluorescence imaging), VisualSonics Vevo 700 (small-animal ultrasound scanner), VisenMedical FMT2500 (flourescence molecular tomograph), Lavision TriM Scope (multi-photon microscope), Scanco vivaCT (Small animal computed tomography), Novotec MicroScope (micro-CT device), Bruker ClinScan 7 Tesla (Magnetic Resonance Imaging (MRI) System), Intravital videa microscopy (e.g. BX50WI fluorescence microscope, Prairie Technologies Ultima Two-Photon Microscope) Cell analysis Laser-Microdissection. FACSArray and AutoMACS in BSL3, MoFlo cell sorting.

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