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Research Area G: IRN NOD-like Receptors - Archetypal Sentinels of Barrier Function

Leader of the RA: Philip Rosenstiel (molecular medicine & cell biology)

NOD-like receptors (NLRs) comprise a family of cytosolic proteins that have been implicated as ancient cellular sentinels mediating protective immune responses against intracellular pathogens.  Genetic variants in NLR genes have been associated with complex chronic inflammatory barrier diseases (e.g. Crohn dis­ease, bronchial asthma). The orchestrated efforts include comprehensive analysis of NLR signaling path­ways, identification of the molecular structure of the NLR/ligand complex and approaches to dissect the crosstalk of NLRs with the adaptive immune system. Based on a population-based description of genetic variability in NLR genes, functional impact of variability will be further investigated in invertebrate in vivo models (transgenic Hydra and murine models) that allow the dissection of the role of NLRs for maintaining the immunological integrity of different barrier organs. The project integrates expertise and infrastructures of Research Areas A-E to form a network of scientific excellence that will drive an interdisciplinary under­standing of the biology of NLRs in the context of barrier disorders and inflammation.

Scientists (young/new scientists underlined)

Thomas Bosch, Stefan Ehlers, Nicolas Gisch, Guntram Grassl, Joachim Grötzinger, Jürgen Harder, Rolf Hilgenfeld, Christoph Hölscher, Sascha Jung, Dieter Kabelitz, Simone Lipinski, Susanna Nikolaus, Eva Philipp, Ehrhardt Proksch, Andrea Rittger, Paul Saftig, Stefan Schreiber, Andra Schromm, Thomas Schwarz, Meike Teschke, Andreas Tholey, Ulrich Zähringer

Resources

Next-generation sequencing technology (Illumina, Solid, 454 GS-Flx) confocal laser microscopy (Zeiss LSM510), FACSAria, Multi-photon microscopy (Lavision TriMScope), mass spectrometry (e.g. Applied Biosystems 4700 MALDI TOF/TOFBruker Daltonics Nano-LCX-Coupled ESI-Ion Trap Mass spectrometer), 2-D Differential Gelelektophorese (DIGE), automated siRNA Platform with genome wide libraries

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