Summer School

"Molecular Interactions at Barriers in Inflammation"

University of Lübeck, Germany

6th to 17th of August 2012

Organized by the Cluster of Excellence "Inflammation at Interfaces"

Coordinators: Prof. Thomas Bosch, Prof. Rolf Hilgenfeld, Prof. Jörg Köhl, Prof. Ulrich Schaible, Prof. Stefan Schütze, Prof. Andreas Tholey

The Summer School will comprise two modules: one week with daily lectures at the University of Lübeck (08/06/2012-08/10/2012) and one week with lab courses (08/13-2012-08/17/2012) at the Universities of Lübeck and Kiel.

At the sommer school, attendants will have the opportunity to meet and discuss cluster research projects with faculty and young researchers, who will present their work as posters

Theoretical Part (Lectures):

Excellent researchers will present the current knowledge within the following fields:

• Immune response in inflammatory diseases
• Host-pathogen interaction in health and disease
• The microbiome in environment and evolution
• Lipidomic-sphingolipid signaling in health and diseases
• Analysis of molecular processes in inflammation and infection

Confirmed speakers:

Immune response

• Jörg Köhl  (University of Lübeck): Complement as an immune sensor and regulator of innate and adaptive immune responses
• Claudia Kemper  (King’s College, London): New concepts in human Th1 regulation by innate signals
• Peter Zipfel (HKI Jena): A lesson learned from pathogenic microbes -complement and innate immunity control homeostasis
• Norbert Reiling (Research Center Borstel): When the WNT blows.... Novel functions of an evolutionarily conserved signaling system in the regulation of inflammation
• Tamas Laskay (University of Lübeck):  Neutrophil granulocytes: The contribution of cell death to antimicrobial defense and to the resolution of inflammation
• Björn Rabe (Kiel University):  Principals of Cytokine signaling
• Rudolph Manz (University of Lübeck): The multiple roles B cells play for induction and suppression of inflammation
• Marc Ehlers  (University of Lübeck): Antibodies: subclasses, effector functions and sugars

Host-Pathogen Interaction

• Stefan Ehlers (Kiel University/Research Center Borstel):  The granuloma in tuberculosis: a host-pathogen collusion
• Ulrich Schaible (Research Center Borstel): The cell biology of intracellular bacterial infections with a focus in   tuberculosis.
• Jan Rupp (University of Lübeck):  Imaging of host-pathogen metabolic activities in living cells
• Norbert Tautz (University of Lübeck): Deregulation of viral replication in lethal mucosal disease
• Guntram Grassl  (Research Center Borstel/Kiel University): How Salmonella breaches the barrier and causes disease
• Christoph Hölscher (Research Center Borstel): Granuloma necrosis in Mycobacterium tuberculosis-infected IL-13-overexpressing mice: Resemblance to human pathology?
• Thomas Peters  (University of Lübeck): Identification and characterization of virus-receptor interactions using NMR experiments
•  Nicole Fischer (UKE Hamburg): Virus hunting using array and sequencing technologies
• Albrecht von Brunn (Ludwig-Maximilians-Universität München):Applying Systems Biology to Virus-Host Interactions

The microbiome in environment and evolution

• Thomas Roeder  (Kiel University):  How Drosophila epithelia control microbial communities 
• John Baines (Max-Planck.Institute Plön/ Kiel University):  Evolutionary and ecological forces shaping diversity in the intestinal microbiota
• Philip Rosenstiel (Kiel University): Genome-Genome Interactions at the Intestinal barrier
• Hinrich Schulenburg (Kiel University):  Experimental evolution as a tool to dissect the dynamics and genomics of host-parasite interaction
• Thomas Bosch  (Kiel University): Living in a Microbial World
• Juris Grasis (San Diego State University): Towards understanding the evolution of host-virus interactions

Lipidomic-sphingolipid signaling in health and disease

• Monica Palmada (University of Duisburg-Essen):  "Sphingolipid involvement in infectious diseases"
• Dieter Adam (Kiel University): Regulation of necroptosis and lysosome size via acid and neutral sphingomyelinase
• Stefan Schütze (Kiel University): Compartmentalization of Ceramide production in Tumor Necrosis Factor Receptor-1 signaling
• Martin Krause (Kiel University): Airway epithelial injury in mechanical ventilation
• Otto Holst (Research Center Borstel): Structure and function of certain bacterial glycolipids
• Stefan Uhlig (RWTH Aachen): The role of acid sphingomyelinase in sepsis and acute respiratory failure  
• Konrad Sandhoff (University of Bonn):Sphingolipid catabolism and the lipid phase problem

Molecular processes in inflammation and infection

• Andreas Tholey (Kiel University): Proteomics in host-pathogen Interactions
• Buko Lindner (Research Center Borstel): Lipidomics, a new analytical tool for the characterization of molecular processes in inflammation and infection
• Thomas Gutsmann (Research Center Borstel): Membrane Biophysics in Infectious Disease
•  Ulrich Zähringer (Research Center Borstel): Glycolipids and NMR: Friends or Foes?
• Rolf Hilgenfeld (University of Lübeck): Structural Systems Biology of Virus-Host interactions
• Peter König (University of Lübeck): Multiphoton microscopy to visualize host pathogen interaction

Practical (Laboratory)  Part:

The practical courses are limited to a maximum of 30 students. On Friday 08/17/2012 the course participants will have the possibility to visit the German Electron Synchrotron (Deutsches Elektronen-Synchrotron, DESY)

Lübeck:  

• Structural Biology (organised by Rolf Hilgenfeld) (Monday - Thursday) Duration: 4 days 
• Phenotypic and functional immune analysis in infection (organised by Jörg Köhl) (Monday - Tuesday) Duration: 2 days
• Reverse genetics of   (+)-strand RNA viruses  (organized N. Tautz Wednesday-Thursday) Duration: 2 days

Kiel:     

• Protein Expression of Proinflammatory Cytokines and Identification and Characterization by Mass Spectrometry    (organized by Andreas Tholey and Joachim Grötzinger ) (Monday-Tuesday) Duration: 2 days
• Salmonella-induced immune response (organized by Guntram Grassl) Duration: 2 days
• Drosophila as model for epithelia immunity (organized by Thomas Roeder) Duration: 2 days
• Principals of  limited proteolysis of cytokine receptors (organized by Björn Rabe) Duration: 2 days

Friday 08/17/2012 Visit of the Structure biology laboratory at the German Electron Synchrotron (Deutsches Elektronen-Synchrotron DESY)

Application for courses spanning the whole week ( 2x 2 days or 1 X 4 days + visit to DESY optional) are desirable and will be preferred

Summer School Stipends

The summer school is part of the DFG Cluster of Excellence Inflammation at Interfaces. This international meeting has a special focus on young scientists with research experience at the late phase of their PhD.Young scientists at the early postdoctoral level are also encouraged to apply.  A limited number of travel grants will be available for highly qualified young researchers, taking into account the cheapest travel connections (up to 100 € for cluster members, 200 € for national and 400 € for international applicants).

Registration details:

• There is no registration fee!
• Deadline for registration is June 30th, 2012
• The theoretical part (08/06-08/10/2012) can be attended without attending the pratical part
• Participants of the practical courses (08/13/2012)  have to attend the theoretical part
• Number of participants:
  
  • A maximum of 50 students can attend the lecture part of the Summer School
  • The practical courses are limited to a maximum of 30 students altogether (preferentially PhD students and young postdocs)
• Travel grants will be available
• Application procedure:

The application form can be send via e-mail to Dr. Claudia Gey (cgey@uv.uni-kiel.de), via fax (+49 451 500 4815) or as printed version to the cluster office at below-mentioned address. If you would like to attend only at the theoretical part please send the filled application form. If you would like to attend at the lab courses or if you want to apply for a travel grant please add your CV and an abstract of your scientific work (not more than 1 page). Please do not forget to indicate which lab course you would like to attend.

Application form here

Information for applicants:

Dr. Claudia Gey (cgey@uv.uni-kiel.de)

Tel.: +49 451 500 4117

Fax: +49 451 500 4815

Written application can be send to:

Geschäftsstelle des Exzellenzclusters Entzündungsforschung

Christian-Albrechts-Universität zu Kiel

Christian-Albrechts-Platz 4

D-24118 Kiel